连续性肾脏替代治疗抗凝技术

Anticoagulation technology during continuous renal replacement therapy.

连续性肾脏替代治疗(CRRT)是一连续、长时间的治疗过程,对于血液在体外循环的抗凝技术是保证CRRT顺利进行的重要措施。本文简述了CRRT中抗凝的基本原则、技术类型和监测目标,同时对于临床常用的肝素抗凝、无肝素法以及局部枸橼酸钠抗凝作了详细介绍,强调合理抗凝应遵循个体化原则,抗凝剂的正确选择和密切的临床监测对防止并发症非常重要。

Since continuous renal replacement therapy （CRRT） is a continuous treatment, extracorporeal anticoagulation is an important measure to ensure the success of CRRT. We briefly describe the basic principles, modes and monitoring objectives of anticoagulation in CRRT. Besides, heparin anticoagulation, anticoagulation without heparin and regional citrate anticoagulation （RCA）are presented in details. We emphasize that anticoagulation mode should be individualized, and the correct selection of anticoagulation mode and intensive clinical monitor are essential to prevent complications.