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化学生物组合法合成米格列醇及其表征 被引量：1

Synthesis and characterization of miglitol by combined biotechnological-chemical synthesis method
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摘要 以葡萄糖和乙醇胺为原料,催化加氢生成N-羟乙基葡糖胺,葡萄糖转化率为89%。氧化葡萄糖酸杆菌Gouv2007的静息细胞在通气下氧化N-羟乙基葡糖胺脱氢生成米格列醇的前体物质6-脱氧-6-羟乙基氨基-α-L-呋喃山梨糖,再催化加氢生成米格列醇,对从N-羟乙基葡糖胺生成米格列醇的底物转化率为77.3%。采用熔程测定、红外光谱分析、质谱分析对N-羟乙基葡糖胺和米格列醇进行了表征,结果表明:所合成的产物分别被鉴定为N-羟乙基葡糖胺和米格列醇。 Glucose and ethanolamines were catalytic hydrogenated to obtain N-（2-hydroxyethyl）- glucamine, with a transformation rate of 89%. N-（2-hydroxyethyl）-glucamine was dehydrogenated to 6-（2-droxyethyl）amino-6-deoxy-α-L-sorbofiuanose the key intermediate of miglitol by the resting cells of Gluconobater oxydans Gouv2007 through aeration. 6-（2-Droxyethyl）amino-6-deoxy-a-Lsorbofiuanose was hydrogenated catalyticlly to miglitol. In the transformation of N-（2-hydroxyethyl）- glucamine to miglitol, the transformation rate was 77.3%. The samples of N-（2-hydroxyethyl）- glucamine and miglitol were characterized with infrared spectroscopy, melting point and MALDI-MS analysis. The results confirmed the samples of N-（2-hydroxyethyl）-glucamine and miglitol.
作者 王端好 孙蓓 赵彭花 薛小波 张小里
机构地区 西北大学化工学院
出处 《化工进展》 EI CAS CSCD 北大核心 2009年第3期477-480,共4页 Chemical Industry and Engineering Progress
关键词 氧化葡萄糖酸杆菌 N-羟乙基葡糖胺 微生物氧化 米格列醇 Gluconobateroxydans N-（2-hydroxyethyl）-glucamine microbial oxidation miglitol
分类号 TQ463 [化学工程—制药化工]
  • 相关文献

参考文献8

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二级参考文献6

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共引文献3

同被引文献8

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化工进展
2009年 第3期

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