α-2b干扰素与胸腺肽联合甘草酸二铵治疗慢性乙型肝炎的效果

INTERFERON-α2b AND THYMOSIN COMBINED WITH DIAMMONIUM GLYCYRRHIZINATE FOR CHRONIC HEPATITIS B

目的观察α-2b干扰素、胸腺肽联合甘草酸二铵治疗慢性乙型肝炎的效果。方法将60例HBeAg阳性的慢性乙型肝炎病人随机分为A、B两组。两组病人均隔日肌肉注射α-2b干扰素300万单位,并加用胸腺肽60 mg静脉滴注,每天1次。A组加用甘草酸二铵150 mg静脉滴注,每天1次。疗程均为6个月。用药前和用药后第1、2、6个月各检测1次肝功能、乙型肝炎病毒(HBV)的血清标志物和HBV DNA。治疗结束后每3个月复查1次HBV DNA和谷丙转氨酶(ALT),随访6个月。结果A组甘草酸二铵治疗开始第1、2个月,ALT下降明显(t=9.327、12.671,P<0.05)。而疗程结束及随访6个月,两组的ALT复常率、HBeAg/抗-HBe转换率和HBVDNA转阴率差异无显著性(P>0.05)。结论α-2b干扰素、胸腺肽联合甘草酸二铵治疗HBeAg阳性慢性乙型肝炎不能增强抗病毒作用,但能减少转氨酶一过性升高,提高病人依从性,可考虑合用。

Objective To observe the efficacy of interferon-α2b and Thymosin combined with diammonium giycyrrhizinate （DG） for chronic hepatitis B （CHB）. Methods Sixty CHB patients were randomized to two groups： Interferon-α2b （3 000 000 U） and Thymosin （60 mg）, IV drop, once a day, were given to both groups; DG （150 mg, IV drop, once a day） was added to group A besides. The course of treatment was six months for both groups. The liver function, serum markers, and HBV DNA were detected before treatment and on the first, second and sixth month after treatment. After completion of therapy, HBV DNA and ALT were detected every three months and followed for six months. Results ALT in group A declined significantly on the first and second month after treatment （t=9. 327,12. 671 ;P〈0.05）. But at the end of treatment and during follow-up period, the differences of ALT recovery rate, HBeAg/anti-HBe transfer ratio and HBV DNA between the two groups were not significant （P〉0.05）. Conclusion The combination of Interferon-α2b, Thymosin and DG cannot enhance anti-virus effect in the treatment of chronic hepatitis B, but can reduce the transient elevation of transaminase, increase the patient＇s compliance.