甘精胰岛素联合药物治疗老年2型糖尿病观察

Effect of Insulin Glargine Combined with Repaglinide or Acarbose on Elder Patients with Type 2 Diabetes

目的比较甘精胰岛素分别联合阿卡波糖及瑞格列奈治疗老年2型糖尿病的疗效。方法9例老年2型糖尿病患者停用原治疗方案,随机分为A组(阿卡波糖组)、B组(瑞格列奈组),两组每天早上皮下注射甘精胰岛素,A组口服阿卡波糖150～300mg/d,B组口服瑞格列奈3～6mg/d,并根据空腹血糖情况调整药物用量,共治疗12周。对比分析两组空腹血糖(FPG)、餐后2h血糖(PPG)和糖化血红蛋白(HbA1c)控制情况及低血糖发生情况。结果治疗后两组FPG、PPG、HbA1c均较治疗前明显下降(P<0.05)。结论甘精胰岛素联合阿卡波糖或瑞格列奈能较好的控制老年2型糖尿病患者血糖及糖化血红蛋白。

Objective To study the effect of insulin combined with repaglinide or acarbose on elder patients with type 2 diabetes（T2DM）. Methods 49 cases elder patients with T2DM complicated with hyperglycemia（fasting plasma glucose 〉 9 mmol/L） were treated with insulin glargine combined with repaglinide or arcabose for 12 weeks. Outcome measures were fasting plasma glucose,2 h postprandial plasma glucose, HbA1 c, and hypoglycemia. Results The excellent control of plasma glucose was achieved after 12 weeks treatment with insulin glargine combinant with repaglinide or arcabose （P 〈 0.05 ）. Conclusion Isulin glargine combined with repaglinide or arcabose can control high plasma glucose well on elder patients with T2DM and the incidence of hypoglycemia is low.