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人椎旁肌组织褪黑素受体的表达 被引量：2

THE EXPRESSION OF MELATONIN RECEPTOR IN PARASPINAL MUSCLES
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摘要 目的了解褪黑素(Mel)受体亚型在人椎旁肌组织的分布。方法应用单克隆抗体免疫组化染色方法检测Mel受体亚型在人椎旁肌组织的分布。结果在人椎旁肌组织中均存在Mel受体mt1和MT2亚型的表达,阳性颗粒分布于细胞浆和细胞核,主要分布于细胞浆。结论人椎旁肌组织存在Mel受体,Mel缺乏可能引起Mel受体介导的椎旁肌的生物效用发生紊乱而影响其对称性生长,从而发生脊柱侧弯。 Objective To study the distribution of melotonin receptor （MR） subtype in paraspinal muscles. Methods MR mt1 and MT2 were detected by monoelonal antibody immunohistochemistry. Results mt1 （Mel 1a） and MT2 （Mel 1b） subtype of MRs were found in the paraspinal muscles, which were localized in cytoplasm and nucleus, mainly in cytoplasm. Conclusion MRs exist in human paraspinal muscles. Lack of MRs may lead to disorder of biologieal effect of the muscles and affect their symmetric growth, thus develop idiopathic scoliosis.
作者 刘金钊 陈晓亮 胡有谷
机构地区 青岛大学医学院附属医院骨科
出处 《青岛大学医学院学报》 CAS 2009年第1期7-8,共2页 Acta Academiae Medicinae Qingdao Universitatis
关键词 受体 褪黑激素 胸椎 肌 人 Receptors, melatonin Thoracic vertebrae Muscles Man
分类号 R341 [医药卫生—基础医学]
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参考文献10

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共引文献8

同被引文献24

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青岛大学医学院学报
2009年 第1期

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