扩张型心肌病与氧自由基关系的研究

Research into the relation of dilated cardiomyopathy and oxygen free radical

为了探讨扩张型心肌病（ＤＣＭ）与氧自由基（ＯＦＲ）的关系，测定了６０例ＤＣＭ患者血浆ＬＰＯ，红细胞ＳＯＤ，全血ＧＳＨＰＸ，并计算ＧＳＨＰＸ／ＬＰＯ比值。结果：ＤＣＭ患者ＬＰＯ明显高于对照组，ＳＯＤ及ＧＳＨ－ＰＸ、ＧＳＨＰＸ／ＬＰＯ明显低于对照组，心功能ＩＶ者ＬＰＯ明显高于心功能Ⅰ、Ⅱ级者。心功能Ⅲ、Ⅳ者ＳＯＤ明显低于心功能Ⅰ、Ⅱ级者。心功能分级与ＬＰＯ明显正相关，与ＳＯＤ、ＧＳＨ－ＰＸ／ＬＰＯ明显负相关。结论：ＤＣＭ患者存在明显脂质过氧化损伤；且心衰越重越明显。提示ＯＦＲ可能参与了ＤＣＭ及其心衰的形成与发展。

In order to research the relation of dilated cardiomyopathy(DCM) and oxygen free radical(OFR), plasma lipid peroxides(LPO), red blood cell(RBC) superoxide dismutase(SOD) and blood glutathione peroxidase(GSHPX) in 60 patients with DCM were measured and the ratio of GSHPX/LPO was counted Results: The levels of plasma LPO in these patients were significantly higher than that in controls while the levels of RBC SOD and GSHPX were significantly lower, and the ratios of GSHPX/LPO were significantly lower too The levels of plasma LPO in the patients with cardiac function grade Ⅳ were significantly higher than that in the patients with cardiac function grade Ⅰ and Ⅱ but the levels of RBC SOD in the patients with cardiac function grade Ⅲ and Ⅳ were significantly lower than that in the patients with cardiac function gradeⅠand Ⅱ Cardiac function grade was in positive correlation with the levels of plasma LPO and in negative correlation with the levels of RBC SOD and the ratios of GSHPX/LPO Conclusion: Lipid peroxidation occurs in the DCM patients ,as the heart function deteriorated the lipid peroxidation increased The results indicate that OFR may play a role in formation and development of DCM and it's heart failure