夏枯草镇静与催眠作用的初步研究

Study on the Sedative and Hypnotic Effects of Spica prunellae

目的研究比较夏枯草不同提取物的镇静、催眠作用。方法采用镇静、催眠实验方法,观察夏枯草不同提取物对小鼠自主活动的影响以及对戊巴比妥钠小鼠睡眠的协同作用。结果夏枯草醇提物及其氯仿萃取部位和醋酸乙酯萃取部位均能明显减少小鼠自主活动次数,增加阈下剂量戊巴比妥钠致小鼠睡眠只数,延长阈上剂量戊巴比妥钠致小鼠睡眠时间。结论夏枯草醇提物及其氯仿萃取部位和醋酸乙酯萃取部位均具有明显的镇静、催眠作用。

Objective To study the sedative and hypnotic effects of the different extracts of Spica pruneUae. Methods Sedative and hypnotic experiments were made to observe the effects of different extracts of Spica prunellae on spontaneous motion and hy- ponosis in mice. Results The ethanol extract of Spica prunellae together with its chloroform extract and ethylacetate extract could markedly inhibit spontaneous motion, enhance the sleeping number of pentobarbital sodium （ subthreshold dosage ） and prolong the sleeping time of sodium pentobarbital （ superthreshold dosage ）. Conclusion The ethanol extract of Spica prunellae together with its chloroform extract and ethylacetate extract has obvious sedative and hypnotic effects.