氯化铝催化假性紫罗兰酮环化反应的研究

Study on Cyclization of Pseudoionone Catalyzed by Aluminium Chloride

首次将Lewis酸催化剂氯化铝应用于假性紫罗兰酮环化反应。该催化剂能有效促进假性紫罗兰酮闭环,具有工艺条件温和、后处理简单、易于操作等特点。通过工艺优化获得了较佳的反应条件:反应温度0℃,催化剂与原料质量比3:4,反应时间3h。用GC-MS方法进行分析表明,氯化铝催化环化假性紫罗兰酮生成了β-紫罗兰酮与二氢-α-紫罗兰酮,产率分别为45.54%和43.55%,假性紫罗兰酮总转化率96.00%。氯化铝催化剂可重复使用,无污染产生,具有绿色合成的特点。

The Lewis acid catalyst aluminium chloride was first used as catalyst for cyclization of pseudoionone in this study. Catalyst can effectively promote cyclization of pseudoionone. The process had characters of mild condition, simple post-processing and easy operation. The optimum conditions were determined as follows：temperature 0 ℃, mass ratio of AlCl3 to pseudoionone 3 ： 4,reaction time 3 h. The constituents of product were determined by GC-MS. Using AlCl3 as catalyst, pseudoionone was synthesized into β-ionone and dihydro-α-ionone. The yields ofβ-ionone and dihydro-α-ionone were 45.54 % and 43.55 % , respectively. The conversion rate of pseudoionone was 96.00 %. In addition,the catalyst of high activity could be reused repeatedly. The process gives no pollution and has characters of green synthesis.