救必应的化学成分研究

Study on Chemical Constituents of Ilex rotunda Thunb

对救必应根皮的化学成分进行了系统研究。从其中分离并鉴定了12个化合物,分别为铁冬青酸(Ⅰ)、坡模醇酸(Ⅱ)、具栖冬青苷(Ⅲ)、苦丁冬青苷H(Ⅳ)、3-O-α-L-吡喃阿拉伯糖-3β,19α-二羟基齐墩果烷-12-烯-28-酸-28-O-β-D-吡喃葡萄糖酯(Ⅴ)、丁香脂素4′-O-β-D-吡喃葡萄糖苷(Ⅵ)、咖啡酸4-O-β-D-吡喃葡萄糖苷(Ⅶ)、香草酸4-O-β-D-吡喃葡萄糖苷(Ⅷ)、丁香苷(Ⅸ)、芥子醛葡萄糖苷(Ⅹ)、β-谷甾醇(Ⅺ)和胡萝卜苷(Ⅻ)。其中,化合物Ⅱ、Ⅳ～Ⅷ为首次从该植物中分离得到。

Chemical constituents of the cortex of iron holly （Ilex rotunda Thunb. ） were studied. Twelve compounds were isolated, and their structures were identified as rotundie acid （Ⅰ）, pomolie acid （Ⅱ）, pedunculoside（Ⅲ）, kudinoside H （Ⅳ）, 3β-[ （α-L-arabinopyranosyl）oxy]-19α-hydroxyolean-12-en-28-oic acid 28-O-β-D-glueopyranosyl ester （Ⅴ）, syringaresinol 4′-O-β-D-glucopyranoside （Ⅵ）, caffeic acid 4-O-β-D-glucopyranoside （Ⅶ）, vanillic acid 4-O-β-D-glucopyranoside （Ⅷ）, syringin （Ⅸ）, sinapaldehyde glucoside （Ⅹ）, β-sitosterol （Ⅺ） and β-daucosterol （Ⅻ）. Among them, compounds Ⅱ, Ⅳ-Ⅷ were isolated from this plant for the first time.