摘要
目的:研究芦荟大黄素对大鼠急性胰腺炎(AP)炎性介质的作用。方法:应用牛黄胆酸钠制备大鼠AP模型,将54只大鼠随机分为假手术组、AP模型组、芦荟大黄素治疗组。术后3、6、12h各处死6只,测定AP大鼠血小板活化因子(PAF)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的水平。结果:芦荟大黄素治疗组与AP模型组比较,血清中PAF及IL-6、TNF-α水平明显低于重症急性胰腺炎模型组。结论:PAF、IL-6及TNF-α水平的降低可能与芦荟大黄素对它们的抑制作用有关。
Objective： To research the effect of Aloe-emodin on inflammatory mediators during acute pancreatitis （AP） in rats. Methods： A total of 54 rats were randomly divided into sham operated group, AP group And aloe-emodin group. The AP rats models of AP used sodium taurocholate. The rats in three group were killed 3, 6 and 12 h after operation to test the platelet-activating factor （PAF）, IL-6 and TNF-α in different phases. Results： The serum levels of PAF, IL-6 and TNF-α of Aloe-emodin group were significantly decreased compared with the AP group. Conclusion： Aloe-emodin may inhibit inflammatory mediators to decreased the levels of PAF, IL-6 and TNF-α.
出处
《中国医药导报》
CAS
2009年第6期14-15,共2页
China Medical Herald
