生殖异常与染色体异态性关系的探讨

Study of Relatonship between Abnormal Reproeductive Activity and Chromosomal Polymorphism.

对2406例生殖异常患者进行D/G组染色体的着丝粒区(cen)和随体区(s)、副缢痕区(qh)、Y长臂(Yq)增加和9号臂间倒位等染色体异态性进行研究,发现异态率12.55％。自发流产、死胎、出生缺陷、无精子症、精子畸形、闭经、不孕患者染色体异态率分别为12.81％、9.18％、14.02％、14.18％、19.44％、8.92％、7.14％。各种类型染色体异态率inv(9)为1.08％、qh+1.83％、D/Gs+3.37％、D/G着丝粒增加0.37％、大Y11.45％。随着流产次数增加异态率亦明显增加,研究结果表明染色体异态与生殖异常有关。

The chromosomal polymorphism of centromere and satellite of D/G, secondary constriction of No. 1, 9, 16 chromosomes and Yq + from 2 406 patients with abnormal reproductive history were analyzed. Our results indicated that the rate of chromosomal polymorphism is 12.55%. They are 12. 81% of spontaneous abortion, 9. 18% of stillbirth, 14.02% of birth defects, 14.18% of aspermia, 19. 44% of sperm malformation, 8. 92% of amenorhea and 7. 14% of female infertility. There were 1.08% of inv(9), 1.83% of qh+ ,3.37% of D/ Gs+ors- ,0.37% of cen+ ,11.45% Yq+in the abnormal reproductive patients. The frequency of abortion was closely related to the rate of chromosomal polymorphism. It proved the chromosomal polymorphism might cause abnormal reproductive activity.