C反应蛋白在阻塞型睡眠呼吸暂停低通气综合征与冠状动脉粥样硬化性心脏病关系中的作用

Role of C-reactive Protein in the Relationship between Obstructive Sleep Apnea-hypopnea Syndrome and Coronary Heart Disease

目的探讨C反应蛋白在阻塞型睡眠呼吸暂停低通气综合征(OSAHS)与冠状动脉粥样硬化性心脏病(冠心病)关系中的作用。方法应用散射比浊法测定31例OSAHS合并冠心病患者(OSAHS+CHD组),31例单纯OSAHS患者(OSAHS组)和28例健康志愿者(正常对照组)血清中C反应蛋白(CRP)含量。结果OSAHS+CHD组和OSAHS组血清CRP高于正常对照组(P<0.05);OSAHS+CHD组血清CRP亦高于OSAHS组(P<0.05)。结论血清血清CRP含量增高是OSAHS患者发生冠心病的重要危险因子之一。

Objective To explore the role of C-reactive protein in the relationship between obstructive sleep apnea-hypopnea syndrome （OSAHS） and coronary heart disease （CHD）. Methods The levels of serum C-reactive protein （CRP） in 31 OSAHS patients with CHD, 31 OSAHS patients without CHD and 28 healthy controls was examined, and the relationship of the CRP concentration with the polysomnogram parameters was analyzed. Results The levels of serum CRP in OSAHS patients with CHD and OSAHS patients without CHD were significantly higher compared with the healthy controls（ P 〈 0.05 ）. ＇The level of CRP was also significantly higher in OSAHS patients with CHD than that in OSAHS patients without CHD （ P 〈 0.05 ）. Conclusion The high level of serum CRP might be an important risk factor for the development of CHD in OSAHS patients.