吸入含矽粉尘和煤尘在大鼠肺中滞留的比较研究

Comparative Study on the Retention Effect of the Inhaled Mineral and Coal Dusts in Rat Lung

以大鼠动式吸入染尘方法吸入含矽尘和煤尘２周。用甲酸消化法测定大鼠肺和纵膈淋巴结中的粉尘含量。结果发现在染尘结束后的第３天，煤尘组大鼠肺中的粉尘含量高于矽尘组；９０天后则矽尘组大鼠肺中的粉尘含量高于煤尘组。提示含矽粉尘在肺中滞留较煤尘持久，因而可对肺产生较为严重的损伤。结果也同时证实淋巴系统是肺内粉尘转移的一条重要途径。

he pulmonary retention and physico chemical characteristics of the dust are very important factors in the occurrence of pneumoconiosis.This paper reports a comparative study on the retention characteristics between the inhaled mineral dust and coal dust in rat lung.The dust quantities in the lungs and the mediastinal lymphatic nodes were determined by the formic acid digestion method.The results showed that the pulmonary retention quantities of the coal dust in rats were higher than those of the mineral dust on the third day but lower on the 90th day after exposure for two weeks.The results suggest that the mineral dust can deposit in the lung longer than the coal dust,and the lymphatic system is important for the pulmonary elimination of the dust.