可溶性白细胞介素2受体在乙型肝炎、肝硬化中的临床意义

CLINICAE SIGNIFICANCE OF SOLUBALE INTERLEUKIN-2 RECEPTORS IN PATIENTS WITH HEPATITIS B AND CIRRHOSIS

用ELASA法测定78例乙型肝炎、40例肝硬化患者血清可溶性白细胞介素2受体（SIL－2R），发现重症肝炎组（1276±433μg／ml），慢性乙型活动性肝炎组（765±523μg／ml），急性乙型病毒性肝炎组（513±133μg／ml）及肝硬化组（734±254μm／ml），的SIL－2R显著高于同时测定的40例正常对照组（368±112μg／ml），各组与正常对照组比较除急性肝炎组P值小于0．01外，其余各组P＜0．001；重症肝炎组与其余各组比较P＜0．001。观察还发现反映肝细胞损害程度的血清总胆红素浓度（SB）与SIL-2R之间有密切关系；52例SB≥51．3μmol／L的SIL-2R水平与66例SB＜51．3μmol/L的比较P＜0.001，该研究表明SIL－2R可以反映乙型肝炎、肝硬化病人肝细胞损害程度、病情状态，对临床分型及估计预后有一定的意义。

The levels of soluble interleukin-2 receptor (SIL-2R)were measured by an enzyme-linked assay in sera from patients consisting of 78 cases of hepatitis B and 40 cases of cirrhosis. It was found that SIL-2R concentration of patients with severe heptatitis (1276±433),chronic hepatitis B (765±523),acute viral hepatitis B (513±113)and liver cirrhosis (734±254)was significantly increased when compared respectively with that of the 40 controls (P<0.001,except for acute viral hepatitis P<0. 01). The serum level of SIL-2R was significanty higher in the patients with severe hepatitis than in those with the other types of hepatitis (P<0. 001). The concentration of serum biliribin reflecting hepacytic injury was closely related to SIL-2R level. Among the 118 patients,there was a significant result between the SIR-2R level of 52 cases with SB≥51. 3μmol/L and that of 66 cases with SB＜51. 3μmol/L(P＜0.001). The study shows that increased SIL-2R probably reflects hepacytic damage and clinical condition of hepatitis B and cirrhosis,and thus may have some role in determining clinical type and estimating prognosis.