脑梗死患者血清细胞间黏附分子-1和凝血因子Ⅶ的水平研究及临床意义

Study on serum level of sICAM-1 and FⅦ in patients with acute cerebral infarction and its clinical significance

目的探讨脑梗死患者血清细胞间黏附分子-1(sICAM-1)与血浆凝血因子Ⅶ(coagu lation factorⅦ,FⅦ)的变化及其临床意义。方法本院收治急性脑梗死患者34例,测定其血清sICAM-1水平及血浆活化的FⅦ(FⅦa)、FⅦ抗原(FⅦAg)、FⅦ活性(FⅦc)水平;另取同期脑动脉供血不足患者28例、健康体检者30名进行对照。结果脑梗死患者的血清sICAM-1水平显著高于脑供血不足患者和对照组,差异有统计学意义(P<0.01);小梗死灶的患者血清sICAM-1水平显著低于大、中梗死灶患者,差异有统计学意义(P<0.05)。脑梗死患者的血浆FⅦc、FⅦAg及FⅦa水平显著高于对照组,差异有统计学意义(P<0.01)。结论血清sICAM-1、FⅦc、FⅦAg、FⅦa水平升高与脑梗死的发生、发展及梗死程度有关,可作为脑梗死的辅助诊断指标。

Objective To explore the change of serum level of soluble intercellular adhesion molecule-1 （ sICAM- 1 ） and coagulative factor Ⅶ （FⅦ） in patients with acute cerebral infarction and its clinicae significance. Methods A total of 34 patients with acute cerebral infarction, 28 patients with cerebral insufficiency and 30 healthy subjects were reeluited in this study. Serum levels of sICAM-1, FⅦa, FⅦ Ag and FⅦc were measured. Results Serum levels of sICAM-1 were significantly higher in patients with cerebral infarction than in patients with cerebral insufficiency and healthy subjects （P 〈 0. 01 ）. Serum levels of sICAM-1 were significantly lower in patients with small area of infarction than in patients with middle and large area of infarction（ P 〈 0.05 ）. Serum levels of FVlla, FⅦ Ag and FⅦc were significantly higher in patients with cerebral infarction than in the healthy subjects （ P 〈 0.01 ）. Conclusions Serum levels of sICAM-1, FVlla, FⅦ Ag and FⅦc are correlated with the progress and severity of cerebral infarction. They can be used as auxiliary diagnostic markers in clinical treatment for cerebral infarction.