女性育龄不孕患者生殖道解脲支原体感染及药敏分析

Analysis on Ureaplasma urealyticum infection of genital duct and drug sensitivity in reproductive aged women

目的了解就诊女性育龄不孕患者生殖道解脲支原体(Uu)感染及药物敏感情况。方法收集育龄不孕女性4216份宫颈分泌物标本,用支原体试剂盒进行半定量培养及药敏试验。对照组为240例健康育龄妇女。结果不孕组Uu阳性1871例,阳性率44.4%;健康对照组Uu阳性81例,阳性率33.8%。Uu对抗生素的敏感性依次为:原始霉素100.0%,交沙霉素99.2%,克拉霉素90.4%,强力霉素80.1%,四环素73.9%,红霉素72.7%,阿奇霉素68.6%,氧氟沙星23.5%,环丙沙星17.2%。结论女性育龄不孕患者生殖道Uu感染率高,耐药株多,应依据药敏结果合理用药治疗,提高治疗效果。

Objective To investigate genital duct infection and drug sensitivity of Ureaplasma urealyticum （Uu） in reproductive aged women in our hospital. Methods A total of 4 216 cervical secretions of reproductive aged women from January 2007 to September 2008 were semi-quantitatively cultured, and drug sensitivity test was done by using the mycoplasma kit. Totally 240 cases of healthy reproductive aged women were enrolled as control group. Results Totally 1 871 cases （44.4%） were Uu positive in the patients with genital duct infection,by comparison, 81 cases （33.8%） of healthy reproductive aged women were Uu positive. The sensitive antibiotics in reducing order were as follows： pristinamycin （100%）, josarnycin （99.2%）, clarithromyein （90.4%）, doxycyeline （80.1%）, tetracycline （73. 9%）, erythromycin （72. 7%） and azithromyein （68. 6%）, ofloxaein （23. 5%）, ciprofloxaein （17. 2%）. Conclusion The infection rate of Uu in reproductive aged women is pretty high; there are so many Uu resistant strains. Therefore, antibiotics should be chosen according to drug sensitivity test results.