一种新型的喹啉-4-氨基磷酸酯衍生物的波谱学研究

Spectroscopic Characterization of a Novel Quinoline-4-phosphoramidate Derivative

以2-苯基-4-喹啉酮为原料,通过磷酰化反应将磷酰氮芥引入到2-苯基-4-喹啉酮中,合成了一种新型的喹啉-4-氨基磷酸酯衍生物.应用DEPT、1H-1HCOSY、13C-1HHSQC、13C-1HHMBC等2D NMR核磁共振技术,对该化合物的1H、13C NMR谱的信号进行了全归属;通过飞行时间质谱(TOF-MS)对这种新型的喹啉-4-氨基磷酸酯衍生物的裂解途径进行了分析.

In this study, phosphoramide mustard was coupled to 2-phenyl-4-quinolone by a facile phosphorylation reaction to yield a novel quinoline-4 phosphoramidate derivative. Complete assignment of the ^1H and ^13 C NMR chemical shifts of the compound was obtained using 2D NMR techniques, including DEPT, ^1H-^1H COSY, ^13C-^1H HSQC and ^13C-^1H HMBC. Mass spectrum of the compound was also recorded to study its fragmentation behaviors.