新药替尼泊苷的碳氢NMR信号全归属

Assignment of ^(13)C and ~1H Chemical Shifts of Teniposide

替尼泊苷是从北美鬼臼或西藏鬼臼提取到的鬼臼树脂,经化学成分分离得到鬼臼毒素通过半合成方法获得的衍生物,是一种周期特异性细胞毒药物.作为一种抗肿瘤药物,替尼泊苷已逐渐成为治疗颅内恶性肿瘤的主要化疗药物.本文应用1D NMR和2D NMR实验技术(COSY,NOESY,TOCOSY,gHSQC,gHMBC)研究了其结构,并对其1H NMR、13C NMR谱信号进行了全归属.

Teniposide is a semisynthetic podophyllotoxin obtainable from the extracts of the roots and the rhizomes of May apple or mandrake plant Podophyllum peltatum. As an anticancer agent, Teniposide has become a major chemotherapy drug for the treatment of intracranial malignant tumor. In this study, the ^13C and ^1H chemical shifts of the compound were assigned using 1D NMR and 2D NMR techniques including COSY, TOCOSY, NOESY, gHSQC and gHMBC. Its structure was determined from the NMR data.