新型金属卟啉-5-氟尿嘧啶化合物的合成及抗癌活性

Synthesis and Antitumor Activity of New Metalloporphyrin 5-Fluorouracil Compounds

设计合成了4种新型卟啉-5-氟尿嘧啶化合物，收率27．1％～58．3％，mp〉300℃。确定了合成反应的最佳条件，研究了目标化合物的分离方法。通过红外光谱、紫外光谱、核磁共振谱和质谱测试技术对化合物结构和组成进行了确认。经抗癌活性实验表明，化合物DI、C2、D2对小鼠S180肉瘤生长有明显的抑制作用。

Four new porphyrin-5-fluorouracil compounds were designed and synthesized with yields of 27.1% -58.3% and mp 〉300℃. The reaction conditions were optimized, and the separation method of the target products was explored. The compositions and structures of these compounds were confirmed by IR, UV-Vis, ^1H NMR, and MS. The antitumor activity experimental results showed that D1, C2, D2 compounds inhibited distinctly the growth of cancer S180 in the mice.