紫外分光光度法测定复方电解质葡萄糖注射液(MG3、M3A、M3B、R2A、R4A)中的5-羟甲基糠醛

UV Spectrophotometric Determination of 5-Hydroxymethyl-2-furaldehyde in Electrolytes and Glucose Compound Injection(MG3、M3A、M3B、R2A、R4A)

目的：建立紫外分光光度法测定复方电解质葡萄糖注射液中杂质5-羟甲基糠醛的含量。方法：根据5-羟甲基糠醛的紫外吸收光谱，在284nIn波长处测定吸光度。结果：吸光度与5-羟甲基糠醛的浓度呈良好的线性关系，回归方程为Y=0．1379X＋4．2824×10^-3，相关系数r=0．9999，线性范围为0．1072—5．360μg／ml，检出限为0．032μg／ml。结论：该方法灵敏、简便、准确，可用于复方电解质葡萄糖注射液（MG3、M3A、M3B、R2A、R4A）的质量控制。

Objective ： To establish a spectrophotometric method for quantitative determination of 5 - hydroxymethyl - 2 - furaldehyde in electrolytes and glucose compound injection. Methods ： The absorbance at wavelength of 284 nm was measured. Results ： The absorbance was linearly proportional to the concentration of 5 - hydroxymethyl - 2 - furaldehyde within the range of 0. 107 2 - 5. 360 μg/ml and the detection limit was 0.032 μg/ml. Conclusion ： The method established provides a sensitive, simple and accuracy measurement of 5 -hydroxymethyl- 2 -furaldehyde in electrolytes and glucose compound injection.