关节腔内注射Anti-VEGF对家兔TMJ间接性损伤作用研究

Study on the Effect of Injecting Anti-VEGF into the Articular Cavities after the TMJ Indirect Injury in Domestic Rabbits

目的:研究应用拮抗血管形成因子试剂对于减轻TMJ(Temporomandibular joint)间接性损伤后软骨破坏效果的影响。方法:应用关节病理损伤指数、关节滑膜血管密度积分和关节软骨含量等检测实验组和对照组组织损伤情况。结果:4周及8周实验组软骨含量均高于对照组,两者比较差异有显著性(P<0.05);4周及8周对照组的关节病理损伤指数均高于实验组,差异具有显著性(P<0.05);4周及8周的关节滑膜血管密度积分低于对照组,差异具有显著性(P<0.05)。结论:应用拮抗血管生成剂可显著提高TMJ间接损伤的关节软骨含量,减少新生的血管形成及减轻TMJ间接损伤后关节内炎症。

Objective： To research the impact of cartilage destructive effect after TMJ （ Temporomandibular Joint） indirect injury reduced by applying anti-vascularization factor reagents. Methods：The conditions of the tissue injuries of the experiment group and the control group were detected by observation criteria such as the injury index of articular pathology, the synovial vascular density integration and the articular cartilage contents. Results： The results showed the cartilage contents of the experiment group at the forth and the eighth weeks were higher than those of the control group and there was significant difference between the two groups （ P 〈 0.05 ）. The injury indexes of articular pathology of the control group at the forth and the eighth weeks were higher than those of the experiment group and there was significant difference between the two groups （P 〈 0.05 ）. The synovial vascular density integration of the experiment group at the forth and the eighth weeks was lower than that of the control group and there was significant difference between the two groups （ P 〈 0.05 ）. Conclusion： Using the anti-vascularization factor reagents may obviously enhance the articular cartilage contents of TMJ indirect injury, reduce the newborn vascularization and alleviate the inflammation after TMJ indirect injury.