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D4S2364基因座在山西汉族人群中的遗传多态性研究

Study on Genetic Polymorphism of D4S2364 Locus in Shanxi Han Population
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摘要 目的:通过对D4S2364基因座在山西汉族人群中的研究,获得此STR基因座的群体遗传数据,对其法医学意义进行探讨。方法:应用PCR扩增技术,非变性聚丙烯酰胺凝胶电泳,对D4S2364基因座进行分型。结果:120例个体中D4S2364共检出5个等位基因,11种基因型,基因型频率分布符合Hardy-Weinberg平衡。此STR基因座在中国山西汉族人群中的非父排除率为0.362,个人识别率为0.804。结论:D4S2364基因座在法医学及人类遗传学方面有较高的应用价值。 Objective： To obtain the population genetic data of the STR locus and discuss the significance of forensic medicine by investigating the D4S2364 locus in Shanxi Han population. Methods： The D4S2364 locus was classificated by PCR amplification technique and non denatured polyacrylamide gel electrophoresis. Results： Five alleles and eleven kinds of genotypes were detected from IMS2364 locus of 120 individual cases and the genotypic frequency distribution coincided with Hardy-Weinberg equilibrium. The power of exclusion （PE） was 0.362 and the power of discrimination （PD） was 0. 804 of the STR locus in Shanxi Han population. Conclusion ：The D4S2364 locus has high practical value in forensic medicine and human genetics research.
作者 刘艳琼 张更谦 郭大玮 车莎
机构地区 山西医科大学法医学院
出处 《山西职工医学院学报》 CAS 2009年第1期9-11,共3页 Journal of Shanxi Medical College for Continuing Education
关键词 短串联重复序列 D4S2364 遗传多态性 山西 汉族人群 short tandem repeats D4S2364 genetic polymorphism Shanxi Chinese Han population
分类号 R394.3 [医药卫生—医学遗传学]
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参考文献12

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山西职工医学院学报
2009年 第1期

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