水杨酰胺一步法合成邻羟基苯甲腈

Onestep synthesis of 2-hydroxybenzonitrile from salicylamide

研究了水杨酰胺和三光气在甲苯溶液中合成邻羟基苯甲腈的反应，反应条件为n（水杨酰胺）：n（三光气）=1．0：0．4、反应温度100℃～105℃、反应时间5h。溶剂甲苯回收后，将邻羟基苯甲腈重结晶提纯，产品质量分数为95．1％，收率达90．6％。

Onestep preparation of 2-hydroxybenzonitrile by the reaction of salicy lamide and bis （trichloromethyl） carbonate （BTC） in toluene was studied. The optimum process conditions were detemlined： n （salicylamide） ： n （BTC） = 1.0：0.4, reaction temperature 100℃- 105℃ and reaction time 5 h. 2-hydroxybenzonitrile was purified by recrystallization after toluene was recovered. The assay of 2-hydroxy benzonitrile was 95.1%, and the yield was 90.6 %.