丙烯腈模拟电刀尾气及CO_2气腹与腹腔镜术后呕吐的相关性

Correlation between simulated the end gas of electrical surgery unit-acrylonitrile and the CO_2 pneumoperitoneum and laparoscopic postoperative vomiting

目的:探讨CO2气腹及丙烯腈模拟电刀尾气对腹腔镜术后呕吐的的影响。方法:选择健康家猫,随机分成4组,均采用氯胺酮加苯妥英钠全麻,A组(对照组)仅单纯全麻,B组全麻后模拟CO2气腹,C组全麻CO2气腹后模拟腹腔镜手术,D组全麻后单纯腹腔内注射丙烯腈,然后观察4组呕吐发生情况并分别检测血液和脑脊液内的5-羟色胺、多巴胺的含量。结果:A组与B组呕吐发生情况相比较差异有统计学意义(P<0.05),C组和A组呕吐发生情况相比较差异具有统计学意义(P<0.01),D组与A、B组呕吐发生情况相比较差异有统计学意义(P<0.05),C组和D组相比较差异无统计学意义(P>0.05),术后血液和脑脊液内的5-羟色胺、多巴胺的含量差异均有统计学意义(P<0.01)。结论:在腹腔镜术后呕吐可能与CO2气腹及电刀尾气引起的血液和脑脊液内的5-羟色胺、多巴胺含量的变化有一定的相关性。

Objective：To approach the effect of the CO2 pneumoperitoneum and the end gas of electrical surgery unit during laparoscopy on postoperative vomiting. Methods：45 able-bodied domestic cats were chosen for experimentation. The domestic eats were divided into four groups randomly,group A （control group）,group B , group C and group D. All cats were given anaesthesia with ketamine, merely anaesthesia with ketamine in group A, to simulate CO2 pneumoperitoneum after anaesthesia in group B, to simulate laparoseopy after anaesthesia in group C, group D merely were injected acrylonitrile and then occurrence of vomiting was observed, collect bloods and eerebrospinal fluids were collected in each cat, out ELISA was carried and contents of 5-HT and dopamine in bloods and cerebrospinal fluids were analysed respectively after operation. Results ：There was significant meaning between group A , group B , group C and group D in both occurrence rate of vomiting and contents of 5-HT and dopamine in bloods and eerebrospinal fluids （P〈 0.01 ）. Conclusion ：There was maybe correlation between the occurrence rate of postoperative vomiting and the CO2 pneumoperitoneum and the end gas of electrical surgery unit during laparoseopy.