摘要
目的考察杠柳毒苷在大鼠小肠内的吸收情况。方法采用大鼠在体单向肠灌流模型,用高效液相色谱法对灌流液中的杠柳毒苷进行分析。结果杠柳毒苷在不同浓度下未发现饱和现象,其吸收速率常数(Ka)和表观吸收系数(Papp)基本保持不变。结论杠柳毒苷在小肠的吸收机制为被动扩散,在临床应用及制剂研究中应考虑其吸收机制。
OBJECTIVE To investigate the intestinal absorption kinetics of periplocin in rats. METHODS The intesti nal absorption in small intestine of rats in situ was investigated using perfusion and HPLC methods. RESULTS No saturation phenomenon occurred and Ka and Papp was almost kept unchanged at different concentrations of periplocin. CONCLUSION The result indicates that the absorption of periploein complied with the passive diffusion mechanism. The absorption characters of periplocin would be considered in the clinical application and the preparation research.
出处
《齐鲁药事》
2009年第2期105-107,共3页
qilu pharmaceutical affairs
关键词
杠柳毒苷
大鼠
在体
肠吸收
Periplocin
rats
in situ
intestine absorption
