口腔白斑及鳞癌病理组织中ras癌基因P^(21)蛋白表达

THE EXPRESSION OF P21 PROTEINPRODUCTS RAS ONCOGENE IN ORAL LEUKOPLAKIA AND SQUAMOUS CELL CARCINOMA

口腔白斑及鳞癌为口腔临床中常见的癌前病损和恶性病变。本研究应用免疫组化技术（ＡＢＣ法）检测口腔鳞状细胞癌及白斑组织中ｒａｓ癌基因产物Ｐ２１蛋白的表达。检测结果表明：在４０例口腔鳞癌中Ｐ２１蛋白阳性表达率为９２．５０％；２１例口腔白斑病变中其阳性率为１９．０５％。Ｐ２１阳性表达位于分化差的癌细胞膜及胞浆内，且阳性表达与临床病理分级呈正相关，提示Ｐ２１蛋白检测可以作为癌及癌前病损预后观察的客观指标。

xpression of P21 protein was studied in leukoplakia and squamous cell carcinoma using immunohistochemistry. The results showed: 92.5% of the 40 patiens of squamous cell carcinoma. 19.05% of the 21 patients of leukoplakia were positive for P21 protein. The positive staining appeared in cell membranes and cytoplasms of poor differentiated cancer. The positive degree showed a direct correlation with the grade of pathology.The results suggested that P21 protein examination was an objective target in the setimating prognosis of cancer and cancer.