体外药盒置入胰腺区域动脉灌注治疗重症急性胰腺炎临床研究

Clinical study of local arterial infusion for the treatment of severe acute pancreatitis

目的探讨体外药盒置入胰腺区域动脉灌注(LAI)治疗重症急性胰腺炎(SAP)的临床价值。方法72例SAP患者根据是否行选择性区域动脉灌注给药分成两组,LAI组42例采用LAI治疗,对照组30例经外周静脉给药,比较两组的临床指标。结果LAI组在缓解腹痛、恢复肠功能、减少并发症、缩短抗生素使用时间、降低全身感染发生率等方面均明显优于对照组(P<0.05),使II级SAP患者的死亡率从60.00%降至29.41%。结论LAI在早期治疗SAP方面效果满意,具有重要的临床价值。

Objective To investigate the clinical value of local arterial infusion （ LAI ） for the treatment of severe acute panereatitis （ SAP）. Methods The clinical data of 72 cases of SAP were analyzed, and they were divided into two groups; LAI group and control group. In LAI group, 42 cases were treated mainly by local arterial infusion （ LAI ）. In control group, 30 cases were treated by intravenous infusion. Results Compared with control group, the results of LAI group were much better in abdominal pain relief, recovery of intestinal function, reducing the complications, shorter antibiotic-time, decreasing the incidence of secondary systemic infection, The mortality of SAP class II in LAI group and control group were 29.41% and 60.00% respectively. Conclusions LAI is clinical effective for the treatment of SAP.