室温离子液体催化阿司匹林的合成

Catalytic synthesis of ionic liquids on aspirin at room temperature

研究了以几种1，3-二烷基咪唑离子液体为催化剂来合成阿司匹林的反应，考察了反应时间、酸醇摩尔比等对该反应的影响。结果表明：[BMIm]Br离子液体对阿司匹林的合成有较好的催化作用，最佳反应条件为：n水杨酸：n乙酸酐=1：2，催化剂用量2mL，反应温度80～85℃，反应时间3h，收率可达81．6％。产物和离子液体不溶而分层，便于分离，且离子液体可以重复使用。

The synthesis of aspirin was investigated in various ionic liquids 1,3-dialkylimidazolium . The effects of reaction time and ratio of acid to alcohol on the reaction were examined. Experimental results showed that ionic liquid [ BMIm] Br could be used as a catalyst of aspirin. The optimized esterification conditions were ： nsalicylic acid ： nacetic anhydride = 1 ： 2, catalyst 2mL, reaction temperature 80-85℃,reaction time 3h. The yield of esterification could reach 81.6%. The isolation of desired products could be achieved via simple decantation and ionic liquids could be reused.