奥氮平治疗脑器质性精神障碍的研究

treatment of Psychogeny associated with Brain disease

目的：探讨奥氮平治疗脑器质性精神障碍的有效性和耐受性。方法：对276例脑器质性精神障碍患者进行12周的奥氮平治疗，使用BPRS、TESS评定治疗效果，治疗前后查血常规、尿常规、肝功能、肾功能、血糖、血脂、心肌酶、心电图、脑电图、胸透检查。结果：治疗8周后，BPRS总分减少，与治疗前比较有统计学意义（P〈0．01），TESS显示最常见的不良反应为体重增加、过度镇静、乏力、口干、头晕、肝功异常，但多为一过性，程度轻微。结论：奥氮平可有效治疗脑器质性精神障碍，且不良反应较轻，耐受性好。

Objective：To investigate the effectivity and survivability of Olanzapine in the treatment of psychogeny associated with brain disease. Methods：276 patients of psychogeny associated with brain disease were treated with Olanzapine for 12 weeks. All subjects were evaluated with BPRS and TESS. And patients were checked blood and urine routine, liver and renal function, blood sugar, blood fat, CM enzyme, EKG, EEG, chest fluoroscopic examination. Results： After 8 weeks, the scores of BPRS decreased than pretherapy and there was significant difference（ P 〈 0.01 ） ,The scale of TESS showed the frequent side effects were： Weight gain, over mitigation, debilitation, dry mouth, dizziness, liver function abnormity, and many of these were provisional and little. Conclusions： Olanzapine can treat psychogeny associated with brain disease effectively and has light side effect and good toleration.