瑞美隆治疗躯体疾病伴发焦虑的疗效观察

The effect of mitanpine in the treatment of body disease with anxiety

目的：评价瑞美隆治疗躯体疾病伴发焦虑的疗效。方法：对2005年2月至2007年5月来我院门诊就诊的患者中的躯体疾患伴发焦虑患者进行开放性平行对照研究，对照组用帕罗西汀治疗，为期6周，采用HAMA、CGI量表评定临床效果，以TESS评定不良反应。结果：共33例（瑞美隆17例，帕罗西汀组16例），临床判断瑞美隆与帕罗西汀的显效率分别为58．8％和56．2％，无显著差异，治疗后1周，瑞美隆组HAMA减分率优于帕罗西汀组，治疗2周后无显著差异。不良反应的发生率，瑞美隆组为11．6％，远低于帕罗西汀组的24．6％。结论：瑞美隆是一种疗效好，安全性高，起效快的治疗躯体疾病伴发焦虑的首选药物。

Objective： To accesses the effect of mitanpine in the treatment of body disease with anxiety. Methods： Body disease with anxiety patient were assessed clinical trial of six weeks open randomized . The efficacy was evaluated by clinical judgment , HAMA and CGI . The safety was assessed in terms of TESS. Results： 33 cases of body disease with anxiety were enrolled , 17 were in the treatment of mitanpine and 16 were in paroxitine According the judgment of clinicians , the marked improved rate was 62.1% for mitanpine and 64.4 % for paroxitine There was no significant difference in any efficacy measurement between two groups A week post treatment , the paroxitine group was good than mitanpine group in HAMA decrease number rate , but two weeks post treatment they were no significant difference in any efficacy measurement. Mitanpine group had much lower incidence of side effect （ 11.6 % ） than that of paroxitine group （24.6 % ）. Conclusions： mitanpine is one of efficient and high safety drug in treatment of body disease with anxiety.