BcL-2蛋白表达与卵巢癌细胞凋亡的关系

Relationship between BcL2 Expression and Apoptosis of Ovary Cancer

应用原位末端标记法（ＴＵＮＥＬ）和免疫组化技术对５０例卵巢癌术后石蜡包埋组织切片进行检测发现，卵巢癌组织中有细胞凋亡和ＢｃＬ－２蛋白的表达，二者阳性率分别为６８．００％（３４／５０）和５０．００％（２５／５０）。ＢｃＬ－２蛋白表达与细胞凋亡呈负相关。提示ＢｃＬ－２蛋白可能通过抑制细胞凋亡而参与卵巢癌的发生与发展。

In the experiment,the apoptosis and BcL2 expression were found in 50 samples of ovary cancer by TDT/dUTP Nick End Labeling (TUNEL) and immunohistochemical.The positive rates were 68.00%(34/50) and 50.00%(25/50),respectively and negative correlation was showed.The results indicated that BcL2 expression may participate in occurrence and development of ovary cancer by inhibition of apoptosis.