危重病人并多系统功能衰竭伍用大剂量维生素C治疗的探讨

Observation on the Use of Large Dose of Vitamine C in Critical Patients Accompanied by Multiple Systems Organ Failure

对３８例危重病人并发多系统器官功能衰竭（ＭＯＳＦ）进行了回顾分析，并探讨了伍用大剂量维生素Ｃ（ＶＣ）治疗的可能性。本组病人ＭＯＳＦ的发生器官以肾、肝、心和外周循环发生率最高，其次为肺及消化、神经和凝血系统。ＶＣ治疗组２０例ＭＯＳＦ死亡９例（４５％），对照组１８例死亡１２例（６６．７％）。两组比较前者死亡率低于对照组（Ｐ≤０．０５）。本文结果表明，在综合治疗ＭＯＳＦ的基础上应用大剂量ＶＣ具有一定价值。

38 of critical patients accompanied by multiple systems organ failure (MOSF) and the probable treatment of large dose of vitamine C were analysed in the paper.We revealed that the organ occurrence of MOSF was,in turn,kidney,liver,heart,peripleral circulatory system(shock),lung and digestive,nervous,metabolic and blood coagulation system.The large dose of vitamine C was used in 20 patients with MOSF.9 of them died in this group (45.0%).In control group,12 of 18 patients died (66.7%).For comparison,the death rate was less in the patients used vitamine C than in the control patients (P≤0.05).The results showed that the use of large dose of vitamine C was clinically feasible on the basis of combined treatment of MOSF.