二甲双胍对PCOS患者血清慢性炎症因子及血脂的影响

Effects of Metformin on Inflammation Factors in Patients with Polycystic Ovary Syndrome

目的:探讨二甲双胍对PCOS患者慢性炎症因子及血脂的影响。方法:PCOS患者43例,予二甲双胍治疗3个月,观察治疗前后慢性炎症因子及血脂的改善情况。结果:二甲双胍治疗后PCOS患者LDL-C、血清IL-6、TNFa明显降低,HDL-C明显升高(P<0.05),血清hsCRP明显降低(P<0.01),而HDL-C明显升高(P<0.05)。肥胖型PCOS患者血清hsCRP、IL-6、TNFa降低更为明显(P<0.01)。结论:二甲双胍可明显改善PCOS患者脂代谢,降低血清炎症因子,改善慢性炎症状态,对预防代谢综合征具有重要意义。

Objective： To study the effects of metformin on inflammation factors and blood lipids in patients of polycystic ovary syndrome （PCOS）. Method ： Forty - three women with PCOS were divided into two groups depend on BMI, and were treated with metformin for three months. Chronic inflammation factors and blood lipids were measured in all patients before and after treatment. Result：After three months of treatment, serum levels of C - reactive protein, tumour necrosis factor - alpha, interleukin - 6 decreased more significantly than that in lean PCOS （P 〈0. 01）. Conclusion：Metformin may effectively improve the lipids metabolism, decrease the levels of serum chronic inflammation factors and metabolism syndrome.