预防性应用注射用头孢曲松钠和头孢呋辛钠预防术后感染的效果对比

Comparing the Effect of Preventing use of Synringe Ceftriaxone Sodium and Cefuroxime Sodium for Infection after Operation

目的：观察在胃肠手术围手术期分别预防性应用注射用头孢曲松钠和头孢呋辛钠所达到的预防感染的效果。方法：回顾性分析各种胃肠手术患者305例,随机分头孢曲松钠预防组（n=153）和头孢呋辛钠预防组（n=152）。手术前0.5~1.0 h分别静脉滴注头孢曲松钠（1 g,只用1次）和头孢呋辛钠（0.75 g,连用3 d）。观察和记录患者一般情况、手术有关情况、不良反应及术后感染情况,计算与抗感染有关的治疗成本并进行分析。结果：头孢曲松钠组和头孢呋辛钠组患者术后分别发生7例（4.58%）和14例（9.21%）感染并发症（P=0.992）,差异有显著性意义（X2=5.607,P=0.018）。其他部位（肺、尿路）感染分别为5例和4例,差异无显著性意义（P〉0.05）。二组患者用于预防和治疗术后感染的相关费用,差异有非常显著性意义（Z=14.51,P=0.000）。结论：单剂量头孢曲松钠比多剂量头孢呋辛钠预防胃肠手术部位感染更有效,费用、效果比更好。

Abstract： Objective： To observe the preventive effect of using synringe cefcriaxone sodium and cefuroxime sodium on infection of perioperative of gastrointestinal surgery. Method： 305 cases with gastrointestinal surgery were divided into synrings ceftriaxone sodum （ n = 153 ） preventing group and cefuroxime sodium （n = 152） preventing group randomly, lg synringe ceftriaxone sodium （only once） and 0.75g cefurxime sodium （ for 3 days） were intravenoused respectively 0.5 - 1.0 hour before operation , and then observed and recorded the general data, satus of operation, bad reaction and infection after operation, counted and ana- lyzed the treatment cost of anti - infection. Result： There was 7 cases （4.58% ） and 14 cases （9.21% ）oecured infection after operation in synringe ceftriaxone sodium preventing group and cefuroxime sodium preventing group respectively. There＇s significant difference （X2 =5. 607, P =0.018）. 5 cases and 4 cases infected with lung and urinary tract respectively. Thereg no significant difference （ P 〉0.05 ）. While, There＇s significant difference in the cost of preventing and treating infection between two groups （ z = 14.51, P =0. 000 ）. Conclusion： It＇s more effective, with lower cost to prevent infection after gastro intestinal surgry by single dose of ceftriaxone sodium than multi - dose of cefuroxime sodium.