祁东地区泌尿生殖道支原体感染及耐药性变迁

Study on Urogenital Mycoplasma Infection and Their Antibiotic Susceptibility

目的探讨祁东地区2001-2007年间泌尿生殖道支原体感染状况及其耐药性变化,为临床合理用药提供参考。方法采用珠海丽珠试剂盒培养支原体及检测药敏。结果2006例标本中检出支原体阳性824例,检出率为41.1%,其中解脲脲原体（Uu）703例（85.3%）,解脲脲原体合并人型支原体（Uu＋Mh）93例（11.3%）,人型支原体（Mh）28例（3.4%）。药敏试验结果表明,强力霉素（敏感率83.7%）、交沙霉素（敏感率89.4%）、美满霉素（敏感率86.3%）敏感性较高且较稳定,其次为克拉霉素（敏感率77.9%）和阿奇霉素（敏感率56.7%）,左氟沙星、氧氟沙星、司帕沙星和罗红霉素敏感率逐年降低。支原体感染不同性别患者以及不同型别支原体对抗生素敏感性亦不同。结论祁东地区泌尿生殖道支原体感染以解脲支原体为主,治疗支原体感染宜首选交沙霉素。

Objective To investigate Urogenital Mycoplasma infection and drug sensitivity in Qi Dong from Janary 2001 to December 2007.Methods Mycoplasma were cultivated and their antibiotic susceptibility was detected with Mycoplasma LIV ZON Reagent Box. Results 824 cases were positive mycoplasma among 2006 cases,accounting for 41.1% of the total.Among 824 clinical isolates,703 cases were Ureaplasma urealyticum（Uu） positive（85.3%）,higher than complicated Uu and Mh infection（93cases,11.3%） or Mycoplasma hominis（Mh） infection（28cases,3.4%）.The result of drug sensitivity test showed that Uu Mh and Uu＋Mh isolated from both sexs had different drug resistance.The most sensitive and stable antibiotics were josamycin（the rate of sensitivity 89.4%） and minocyline（the rate of sensitivity 86.3%）,the next was doxycyline（the rate of sensitivity 83.7%）.The lowest rate of sensitivity was to roxthromycin（the rate of sensitivity 22.3%）.It seemed to have an increasing resistance trend for roxthromycin,ofloxacin,levofloxacin,sparfloxacin. Conclusions Urogenital Mycoplasma infection shows principally as Ureaplsmalyticum,josamycin may be selected as the first drug to treat mycoplasma infection.