摘要
目的:探讨β-隐黄质对去卵巢骨质疏松模型大鼠的影响.方法:将72只15周龄SD大鼠随机分为6组,空白组做假手术,其余5组做卵巢切除术,术后用药12周后处死,测定右侧股骨骨密度、骨矿含量、血清雌二醇、碱性磷酸酶含量及子宫湿重.结果:β-隐黄质高、中、低剂量组、尼尔雌醇组能对抗骨密度、骨矿含量、血清雌二醇的下降、血清碱性磷酸酶的升高(与模型组相比P<0.05);各剂量组、尼尔雌醇组能对抗子宫指数的减轻(与模型组相比P<0.05).结论:β-隐黄质可以改善骨质量,抑制大鼠去卵巢骨质疏松的发生,具有类似雌激素的效应.
To study and analyze the effects of β-cryptoxanthin on osteoporosis of ovariectomized rat models.Method： Seventy-two 15 weeks old SD rats were divided into six groups,included control group and five ovariectomized models.After model groups were fed by β-cryptoxanthin for 12 weeks,related indexes were analyzed,including their length bone mineral density,bone mineral,serum estradiol, serum ALP and uterus index.Result： Compared with model group,different does groupes and nilestriol group could increase bone mineral density,bone mineral,serum estradiol and uterus index,but decreased serum ALP（P〈0.05）.Conclusion： As a female sex hormone-like component,β-cryptoxanthin may ameliorate the bone quality and inhibit osteoporosis of ovariectomized rat models.
出处
《首都师范大学学报（自然科学版）》
2008年第5期42-44,共3页
Journal of Capital Normal University：Natural Science Edition
基金
北京市自然科学基金对外合作项目No.SZ20051141720
关键词
骨质疏松症
β-隐黄质
骨密度
雌激素
osteoporosis,β-cryptoxanthin,bone mineral density,female sex hormone.
