AMI患者PCI后血浆黏附分子表达水平的变化

Expression of serum adhesion molecule after PCI operation in AMI patients

目的观察急性心肌梗死患者介入治疗后黏附分子表达水平的动态变化,探讨卡维地洛对黏附分子表达的影响,及其在防治心肌缺血再灌注损伤中的作用。方法急性心肌梗死患者共60例,随机分为对照组(不应用β受体阻滞剂,n=30)和卡维地洛组(n=30)两组。于术后即刻、7 d、3个月用间接免疫荧光法动态检测CD11b、CD18、ICAM-1以及L-selectin的表达。结果两组患者接受PCI术后外周血黏附分子表达水平呈动态变化,卡维地洛组与对照组相比,CD11b、CD18、ICAM-1以及L-selectin的表达水平均明显下降,差别具统计学意义。结论卡维地洛可降低AMI患者黏附分子表达水平,在防治心肌缺血再灌注损伤中具有一定积极作用。

Objective To study the changes of the serum adhesion molecule level in acute myocardial infarction （AMI） patients after percutaneous coronary intervenon （PCI） and the effects of Carvedilol on adhesion molecule expression in order to find the mechanism of Carvedilol on preventing myocardial ischemiareperfusion injury. Methods Sixty patients with AMI were randomly divided into two groups： control group （n =30, βblocker were not used in this group） and Carvedilol group （n = 30）. Expressions of CDllb, CD18, ICAM-1 ,and L-selectin were assessed at three time points （operated immediately, seven days later, three months later） in two groups by indirect immunofluorescence. Results Expressions of CDllb, CD18, ICAM-1 and L-selectin in all patients showed dynamic changes. The levels of CD11 b, CD18, ICAM-1 and L- selectin were significantly lower in Carvedilol group than in control group （ P 〈 0. 05 ）. Conclusion Carvedilol can decrease the expression of adhesion molecule significantly in peripheral blood. It plays an important role in preventing myocardial ischemia-reperfusion injury.