早产儿视网膜病变高危致病因素分析

Monothetic factor analysis of incidence and risk factors of retinopathy of prematurity

目的探讨早产儿视网膜病变(ROP)发生的高危致病因素。方法对2005年1月1日至2008年6月30日在深圳市儿童医院、深圳市妇幼保健院及深圳市眼科医院就诊的胎龄≤34周或出生体重≤2000 g的早产儿进行眼底检查,并对ROP高危致病因素进行多因素分析。结果完成筛查的219例早产儿中,21例(42只眼)发生ROP,占9.6%,其中阈值病变6例(12只眼),占2.7%。单因素分析显示,ROP的发生与出生体重、孕周、首次救治医院有无新生儿重症监护(NICU)、吸氧>5d、窒息以及贫血等6项高危因素有关。结论ROP的发生与孕周短、出生体重低和吸氧时间长有关。

Objective To investigate the incidence and risk factors of retinopathy of prematurity （ROP）. Method From Jan 1st, 2005 to Jun 30, 2008, premature infants with gestational age ≤ 34 weeks or birth weight ≤2000g, born in Shenzhen Children Hospital, Shenzhen Women＇s and Children Hospital, and Shenzhen Eye Hospital underwent fundus examination, and were analyzed the incidence and risk factors of ROP. Results In all the 219 premature infants, 21 （42 eyes, 9.6% ） were found with ROP, 6 （12 eyes, 2.7% ） with threshold ROP. Monothetic factor analysis turned out that the development of ROP was correlated with birth weight, gestational age, NICU supply at the first diagnosis clinic, oxygen uptake time 〉5d, suffocate and anemia. Conclusion Incidence of ROP is higher in infants with shorter gestational age, lower birth weight, and longer oxygen uptake time.