艾滋病并发新生隐球菌脑膜炎13例临床分析

Clinical analysis of thirteen cases of AIDS complicated with cryptococcal meningitis

目的:提高对艾滋病并发新生隐球菌脑膜炎的认识。方法:对2002年9月—2008年3月期间收治的13例艾滋病并发新生隐球菌脑膜炎患者的临床资料进行回顾性分析。结果:13例患者均有发热、头痛、颈项强直等神经系统症状和体征,平均体重47.90 kg,恶病质表现;CD4^+细胞计数11例<0.05×10~9/L,2例在(0.05～0.1)×10~9/L之间,平均0.038×10~9/L。结论:艾滋病并发隐球菌脑膜炎常发生在晚期患者,病情重,预后差,应加强早期预防、早诊断、早治疗。

Objective： To improve the awareness of AIDS complicated with cryptococcal meningitis. Methods： Thirteen cases of AIDS complicated with cryptocoecal meningitis （C.neoformans） admitted from September 2002 to March 2008 were retrospectively reviewed. Results： All the patients were in a status of cachexia and had the symptoms and signs of nervous system, such as fever, headache, stiff-neck and so on. The mean body weight was 47.9 kg CD4＋T cell count was less than 0.05×10^9/L in 11 cases, 0.05-0.10×10^9/L in 2 cases, with a mean level of 0.038×10^9/L. Conclusions： AIDS complicated with ctyptococcal meningitis usually occurred in the advanced stage of AIDS, with serious conditions, poor prognosis and difficult to be treated. It should be prevented early, diagnosed early and treated in time.