乳腺实质X线分型与乳腺癌相关性分析

Relevance analysis of mammographic parenchymal patterns and breast cancer

目的探讨乳腺实质X线分型与乳腺癌相关性,对乳腺癌高危人群实行干预性治疗和定期追查,达到降低乳腺癌发生率和死亡率的目的。方法对500例乳腺癌和1000例对照组病例进行乳腺X线分型,将对照组不同亚型组织切片与乳腺癌组癌周组织切片对照研究,分析乳腺不同亚型乳腺癌的危险度,同时分析乳腺不同亚型在各年龄段发生乳腺癌的危险度。并通过统计学方法作类型分析和乳腺癌发生统计。结果①最低危险组OR<0.3,癌发生率在2%以下的亚型有Ⅰa,Ⅱa,Ⅲa,Ⅳa。②低危险组OR<0.3,癌发生率在2%～5%以下的亚型是Ⅰb型。③危险组OR>0.3癌发生率在5～10%的亚型:Ⅳb,Ⅱb,Ⅲb。④高危险组OR>1,癌发生率超过10%以上的亚型Ⅲc,Ⅳc。乳腺癌高危险年龄段:Ⅳc型和Ⅲc型35～55岁,Ⅲc型可延长至60岁,Ⅳb型31～50岁,Ⅲb和Ⅱb型50～60岁。结论Ⅲc和Ⅳc型属于高危险型,其人群约占癌数的67.4%。是乳腺普查追踪的主要对象,其中35～55岁必须每年复查一次。必要时进行干预性治疗,达到预防乳腺癌,降低乳腺癌发生率及早发现早治疗,提高乳腺癌患者的生存质量,降低死亡率。

Objective Discussing the relativity of Mammographic parenchymal patterns and breast cancer, implementing the intervention treatment and regularly traces to the breast high dangerous crowd, in order to reduce the occurrence rate of beast cancer and the mortality rate. Methods Mammary gland type was marked according to X ray on 500 breast cancer subjects and 1000 control subjects. Peri-cancer histological sections of the subtypes of the breast cancer group and histological section of the subtypes of the control group were studied contrastively to analyze the breast cancer risk index in every subtype and the occurrence rate in every age group, The types and the occurrence rates were counted. Results （1）The lowest risk group： the subtypes with OR 〈0.3 and the cancer incidence rates below 2% were Ⅰa,Ⅱa,Ⅲa,Ⅳa. （2）Low-risk group： the subtypes with OR 〈0.3 and the cancer incidence rate below 2% to 5% were Ⅰ b. （3） Risk group： the subtypes with OR〉 0.3 and the cancer incidence rate ranging from 5% to 10% were Ⅳb,Ⅱb,Ⅲb,（4）High-risk group： the subtypes with OR〉 1 and the cancer incidence rate above 10% were Ⅲ c, Ⅳ c. High dangerous age sections of breast cancer： 35 to 55 years old in Ⅳc and Ⅲc （the age section of Ⅲc may lengthen to 60 years old）, 31 to 50 years old in IVb, 50 to 60 years old in Ⅲb and lib. Conclusion Ⅲc and Ⅳc belong to the high dangerous subtypes. People of these subtypes reach 67.4% of all breast cancer examples, so these people are the main subjects of the mammary gland general survey and tracing. Patient aged from 35 to 55 should be reexamined once a year. When necessary, the intervention treatment may be carded out to prevent breast cancer and to reduce the occurrence rate of beast cancer. Discovery and .treatment in early phase can improve the breast cancer＇s survival quality, and reduce the mortality rate.