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重组毒素MSH-Ang对喉癌Hep-2细胞的毒性作用研究

Research of cellular toxic effect to Hep-2 of recombinant toxin MSH-Ang
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摘要 目的:研究重组毒素MSH-Ang对喉癌Hep-2细胞的毒性。方法:应用纯化的MSH-Ang进行体外细胞毒性实验,观察对喉癌细胞的生长抑制作用。结果:重组蛋白对喉癌细胞的生长有明显抑制作用,随着浓度梯度的增加,其抑制作用明显增强,细胞的死亡率逐渐增大。结论:重组毒素MSH-Ang不仅对已知的高表达MSHR的肿瘤具有特异性杀伤作用,还是一种对多种常见肿瘤细胞具有杀伤功能的导向毒素。 Objective:To study the cytotoxicity of recombinate toxin MSH Ang to Hep-2. Method:The depurated MSH Ang were applied in cytotoxieity experiment, and the growth inhibiting action to laryngeal carcinoma cell Hep 2 were observed. Result: Recombination protein inhibited the growth of laryngeal carcinoma cell Hep-2, and its inhibiting action enhanced and corpuscular mortality rate increased along with the concentration increasing. Conclusion:Recombinant toxin MSH Ang can not only take special effect in tumors with high MSHR, but also target to many other popular tumors.
出处 《临床耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2009年第5期225-226,共2页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词 重组毒素 促黑激素 血管生成素 基因工程 recombinant toxin melanocyte stimulating hormone angiogenin gene engineering
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参考文献5

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