MRI上抽动秽语综合征患者基底节核团体积的变化

MRI volume measurement of basal ganglia volumes in patients with Tourette＇s syndrome

目的探讨MR测量基底节核团体积对抽动秽语综合征（Tourette’s syndrome，聪）病因诊断的价值。方法选取10例TS患者（TS组）和10名健康志愿者（对照组）进行MR扫描，分别测量双侧尾状核、壳核、苍白球的体积，对两侧的基底节体积采用配对t检验进行比较分析；将大脑ROI体积数值进行标准化处理，对TS组和对照组之间基底节体积采用独立样本t检验进行比较分析。结果正常对照组左侧尾状核、壳核、苍白球体积及3者之和均大于右侧（P值均〈0．05），TS组上述结构两侧比较差异无统计学意义（P值均〉0．05）。根据大脑体积进行标准化处理后，TS患者左侧尾状核、壳核、苍白球体积分别为（7．06±0．48）、（8．81±1．01）、（2．64±0．38）cm^3，正常对照组分别为（11．05±1．86）、（9．97±1．11）、（3．04±0．37）cm^3，TS组较对照组减小（t值分别为-6．577、-2．457、-2．376，P值均〈0．05）；TS组右侧尾状核体积[（7．32±0．26）cm^3]较对照组[（9．81±1．83）cm^3]减小（t=-4．258，P〈0．01），右侧壳核、苍白球体积与对照组比较差异无统计学意义（P值均〉0．05）。结论MRI显示TS患者基底节核团体积减小，这对研究其病理生理机制及神经病理变化有一定的价值。

Objective To evaluate MRI measurement of basal ganglia volumes in patients with Tourette＇s syndrome. Methods Ten patients with Tourette＇s syndrome （TS） and 10 healthy volunteers were studied. Volumes of bilateral caudate, putamen and pallidum were measured, and the results were analyzed using paired t test. The basal ganglia volume was normalized according to individual brain volume. The basal ganglia volumes of TS patients were compared with normal control group using independent-sample t test. Results In 10 healthy volunteers,volumes of the left caudate, putamen, pallidum were significantly larger compared with those of the right side （P 〈0. 05）. However, there were no significant differences between bilateral basal ganglia volumes （ P 〉 0. 05 ） in TS patients. After normalized processing, the volumes of the left caudate （7.06 ±0.48） cm^3, putamen （8.81 ± 1.01） cm^3, pallidum （2.64 ± 0. 38） cm^3 were smaller than those of control group [ caudate （11.05± 1.86）cm^3, putamen （9. 97 ± 1.11 ） cm^3, pallidum （ 3.04 ± 0. 37） cm^3 ] （ t = - 6. 577, - 2. 457, - 2. 376, P 〈 0.05 ）. The volume of the right caudate （7.32 ± 0. 26 ） cm^3 in TS patients was significantly smaller compared with the control group （9. 81 ± 1.83） cm^3 （t = -4. 258, P 〈 0.01 ）. However, the volumes of the right putamen and pallidum had no significant difference between two groups （ P 〉 0. 05）. Conclusion The basal ganglia volumes were significantly decreased in patients with TS. MRI volumetric measurement was an important tool for evaluating pathologic changes of TS.