静息状态下帕金森病患者脑部功能连接的MR研究

Magnetic resonance imaging of functional connectivity in Parkinson disease in the resting brain

目的探讨帕金森病患者在静息状态下脑部功能连接情况。方法选取9例Ⅱ-Ⅲ级原发性帕金森病患者及8名年龄分布相同的健康志愿者在静息状态下进行MR扫描，选择双侧苍白球作为种子点，分析其脑部功能连接情况，并采用两样本t检验与健康对照组相比较。结果正常健康对照组中，双侧颞极、双侧海马、双侧丘脑、扣带回后部、右侧枕中区、右侧顶上回等部位存在着功能连接。帕金森病患者的双侧小脑半球、左侧海马、双侧颞上回、后扣带回、左侧额下回、左侧额中回、左侧中央前回、左侧顶下回、左侧顶上回等部位存在功能联系，与对照组相比，帕金森病患者的双侧小脑、双侧颞叶、左侧额叶、左侧运动前区、左侧顶叶等部位存在着功能连接增强，双侧丘脑的功能连接减弱。结论静息状态下，帕金森病脑部存在着功能连接异常现象。

Objective To investigate functional connectivity changes in Parkinson disease in the resting brain using functional magnetic resonance imaging. Methods Nine patients with Parkinson disease and eight age-matched healthy volunteers were entered into the study. The bilateral globus pallidus were chosen as seed points, the functional MR data acquired in the resting state were processed to investigate functional connectivity in PD patients and the results were compared with those of the controls. Results In age-matched healthy controls, there are regions which had functional connectivity with bilateral globus pallidus, including bilateral temporal poles, bilateral hippocampus, bilateral thalami, posterior cingulate cortex, right middle occipital gyrus and right superior parietal gyrus. In PD patients, brain regions including bilateral cerebellum, left hippocampus, bilateral superior temporal gyri, left inferior frontal gyrus, left middle frontal gyrus, left precentral gyrus, left inferior parietal gyrus and left superior parietal gyrus, had functional connectivity with bilateral globus pallidus. Compared to healthy controls, increased functional connectivity in bilateral cerebellum, bilateral temporal lobes, left frontal lobe and left parietal lobe, and decreased functional connectivity in bilateral thalami were observed in PD patients. Conclusion Abnormal changes of brain functional connectivity exists in Parkinson＇s disease in the resting state.