阿胶对诱导排卵周期子宫内膜容受性的作用

Clinical Effectiveness of Colla Corii Asini on Improving Uterine Receptivity in Controlled Ovarian Stimulation

目的探讨阿胶对诱导排卵助孕周期子宫内膜容受性的作用。方法将56例68周期在诱导排卵周期中接受夫精人工授精(AIH)或指导同房助孕治疗的患者随机分为A、B两组,A组为对照组,B组自月经周期第7天开始给予阿胶口服治疗,每天用生胶量30g,至下次月经或证实临床妊娠为止。结果月经周期第7天至排卵日的子宫内膜厚度增长值A组为(3.10±1.32)mm,B组为(3.88±1.54)mm,两组之间差异有统计学意义(P<0.05)。两组子宫内膜厚度每日增加数分别为(0.49±0.23)mm和(0.62±0.26)mm,差异有统计学意义(P<0.05)。阴道彩色B超监测排卵日的子宫动脉血流阻力指数和搏动指数B组较A组明显下降(P<0.05)。结论阿胶能增加诱导排卵助孕周期子宫内膜的厚度,加速子宫内膜的增长并改善子宫动脉血供。

Objective To evaluate the effect of Colla Corii Asini on improving the uterine receptivity in controlled ovarian stimulation. Method A cohort of 56 infertile women, 68 COH cycles followed by AIH or timed sexual intercourse were divided into group A and group B. Patients from group B were administrated Colla Corii Asini 30g per day orally till next menstruation or clinical pregnancy was confirmed while patients from group A were treated without administration of Colla Corii Asini. Result Patients from group B resulted in statistically higher Endometrial thickness and lower Uterine arterial resistance index and pulsatility index. Conclusion Colla Corii Asini administration improves the blood supply of uterine, resulting in improvement of endometrial thickness.