肿瘤中neu基因的过量表达及其抑制

Overexpression and Suppression of neu Gene in Human Cancers.

ｎｅｕ基因编码一种和表皮生长因子受体同源的磷酸蛋白，具有酪氨酸激酶的活性．近年来在多种人类肿瘤中发现ｎｅｕ基因的扩增和（或）过量表达．一些蛋白质因子或化学药物可以在转录水平阻遏ｎｅｕ基因的过量表达或者降低其产物ｐ１８５ｎｅｕ的酪氨酸激酶活性，抑制具有ｎｅｕ基因过量表达的癌细胞的转移和增殖．

The neu gene is known to encode a PTKactivitybearing phosphoprotein which is one of the homologous proteins of epidermal growth factor receptor (EGFR). Amplification and (or) overexpression of neu gene have been found in various human cancers recently. Some protein factors and chemical agents can suppress neu gene transcription or reduce the PTK activity of p185neu, resulting in the inhibition of metastasis and proliferation of cancer cells with neu overexpression.