成纤维细胞生长因子的双受体系统

The Dualreceptor System of Fibroblast Growth Factors.

成纤维细胞生长因子（ＦＧＦｓ）对于细胞代谢的刺激作用是通过双受体系统（ｄｕａｌｒｅｃｅｐｔｏｒｓｙｓｔｅｍ）介导的．该系统包括一个酪氨酸激酶受体家族（ＦＧＦＲｓ）及肝素硫酸蛋白多糖（ＨＳＰＧ）．目前已知有４种ＦＧＦＲｓ基因，其转录过程表现出剪切多样性．ＦＧＦｓ与ＦＧＦＲｓ的结合表现出交叉特异性．ＨＳＰＧ可促进ＦＧＦｓ与ＦＧＦＲｓ的结合和受体二聚体的形成，并增强ＦＧＦｓ对细胞调控的精度．ＦＧＦＲｓ通过激活不同下游信号分子影响细胞有丝分裂、神经细胞轴突生长、胚胎发育等．

The activity of fibroblast growth factors(FGFs)is mediated by a dualreceptor system. This comprises a family of four receptor tyrosine kinases(FGFRs)and heparin sulphate proteoglycans(HSPG). The binding of the FGFs to the FGFRSs is marked by a pattern of overlapping specificity despite alternative splicing events generating a large number of FGFRs.HSPG receptors may stimulate the combination between the FGFs and FGFRs, and provide additional specifity allowing a cell to fine tune its response to the FGFs.FGFRs induce the activities of donwstream signal molecules which then act in different ways that affect the cell′s development, mitogenesis, and neuronal differentation, respectivly.