游泳方法建立大鼠模拟过度训练模型

A Model for Simulating Overtraining in Rats by Swimming

本文报道用超负荷训练大鼠游泳的方法，来建立大鼠模拟过度训练模型。大鼠随机分为３组：（１）对照组；（２）一般游泳训练组，进行中等强度游泳训练；（３）过度负荷组，采用负重的方法增加游泳训练的强度，并在训练的后期，使训练动物反复运动至力竭。结果表明：过度负荷组大鼠在训练的后期，普遍出现了运动能力下降，并且神志、外观等一般状况恶化、体重下降，血清睾酮浓度明显下降，运动后即刻和２４小时皮质酮浓度明显升高，血红蛋白含量下降，尿中蛋白含量升高等异常表现，尤其运动后２４小时，血浆皮质酮浓度仍较高，睾酮／皮质酮比值较对照组下降９４．２％，远远超过３０％的人类过度训练诊断参考标准。作者认为，采用超负荷训练大鼠游泳的方法，来建立大鼠模拟过度训练模型，是可行的。

A model was developed for simulating overtraining in rats by method of swimming training.80 male Wis-tar rats were divided randomly into 3groupl:(1)Control group (C);(2)Normal swimming group(NS),in whichmoderate intensive swimming training was conducted 2 hours per day for 8weeks;(3) Overload swimming group(O) in which training intensity was overloaded by adding weights to rats.By the later stage of the experiment,the rats were exposed to the overload training to exhaustion.The weight of O group rats was no longer increasedafter being exposed to exhaustive training from the sixth week,and decreased in the seventh week.At the endof the experiment,there was an average weight loss of 7.1% for O group rats.Meanwhile,the performance of Ogroup rats was decreased and the general condition was deteriorated.Blood and urine samples examinationsshowed that the concentration of serum testosterone of O group rats was significantly decreased,plasma corticos-terone increased immediately after training and also 24 hours later.Urine protein increased significantly andhemoglobin decreased.The authors concluded that the model for simulating overtraining by swimming trainingwith tats would be feasible.