摘要
目的观察榜嘎总碱对弗氏完全佐剂致关节炎模型大鼠环氧合酶-2(COX-2)、白细胞介素1(IL-1)、肿瘤坏死因子(TNF)、前列腺素E2(PGE2)活性的影响。方法建立关节炎模型大鼠模型。实验大鼠分为空白对照组、模型组、阿斯匹林组、榜嘎总碱低剂量组及高剂量组。用放免法检测COX-2、IL-1、TNF和PGE2活性。结果榜嘎总碱能显著降低模型大鼠血清中COX-2活性及IL-1、TNF和PGE2的含量,并呈现一定的量-效关系。结论榜嘎总碱对关节炎模型大鼠具有明显的抗炎作用。
Objective： To investigate the effect of the total alkaloids of herba aconiti on COX -2 ,IL - 1 ,TNF and PGE2 of arthritis -model rats. Methods： The arthritis -model rats were established by freund＇ s complete adjuvant, and were divided into control group, model group, aspirin group, total alkaloids high- dose group and low- dose group. The COX - 2, IL - 1, TNF and PGE2 were determined by radio - immunity. Result： The total alkaloids on herba aconiti inhibited COX- 2, IL- 1, TNF and PGE2 in arthritis- model rats and showed dose- effect relationship. Conclusion：The total alkaloids on herba aconiti have identified anti -inflammatory effect.
出处
《中国中医急症》
2009年第3期427-428,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
国家支撑计划重大项目(No.07ZQ026-011)
