关于WHO 2005年以来高致病性H5N1禽流感病毒的临床和治疗进展

Progress in treatment of infection with highly pathogenic H5N1 avian influenza virus since 2005

自1997年中国香港特别行政区报道首例人感染H5N1禽流感病毒以来，截至2008年9月10日，这场在禽类中史无前例地持续流行、造成了人类感染并具有高病死率的疫情已经波及到15个国家和地区，总发病387例，死亡245例，其中我国疫情30例，病死率超过60％，防控形势十分严峻。本文旨在整理分析2005年以来世界卫生组织和全球对禽流感病毒临床防治研究成果及人感染H5N1禽流感病例报道的最新信息，力求提供一个防治人禽流感方面的较为全面而清晰的介绍。

Highly pathogenic H5N1 avian influenza virus（AIV） has spread unprecedentedly across the world since the first outbreak of human cases was reported in 1997 in Hong Kong, China. Until June 19th,2008,H5N1 virus resulted in sporadic but severe even fatal human cases in 15 countries,243 died in 385 reported human HSN1 infections,including 20 in China,and the overall mortality was more than 60%. These new appeared viruses and their capacity of transmission from birds to humans have raised a great deal of concern for a potential pandemic,and world health organization has promulgated a few recommendations or guidelines. This review provides an up-to-date information of research in H5N1 virus infection since 2005, and summarizes the epidemiology, clinical features, pathology, diagnosis, current therapeutic options and prevention strategies of H5N1 infection in humans.