人偏肺病毒与呼吸道合胞病毒感染后细胞因子改变的比较

Progress of differential cytokine profiles with human metapneumovirus or respiratory syncytial virus

人偏肺病毒与呼吸道合胞病毒是呼吸道感染的常见病原体，其感染后的发病机制尚不完全清楚，广泛接受的假说是引起机体固有免疫反应。大量研究显示两者产生不同的细胞因子效应，也提示人偏肺病毒感染的发病机制可能有别于呼吸道合胞病毒。本文就目前国内外对人偏肺病毒感染后与呼吸道合胞病毒细胞因子改变的比较研究进行综述。

Virus are the most frequent cause of viral respiratory infections for infants and young children. However, the mechanisms of the diseases that are associated with viral respiratory-tract infection are less clear. A widely accepted hypothesis attributes the pathogenesis of viral respiratory infections to the induction of innate inflammatory responses. Infection with human metapneumovirus was second only to respiratory syncytial virus in frequency. In this review, human metapneumovirus and respiratory syncytial virus elicit different cytokine responses and the pathogeneses of these agents should be studied individually.